反応 #565308

反応方程式

HCl

Methyl 3,5-dichloro-4-hydroxybenzoate

1-bromododecane

potassium carbonate

potassium carbonate

→

Methyl 3,5-Dichloro-4-dodecyloxybenzoate

溶媒

DMF

反応条件

後処理

1. 1
   温度The reaction was cooled
2. 2
   抽出The mixture was then extracted with ethyl acetate
3. 3
   洗浄The ethyl acetate was washed with 2N-HCl(×3)
4. 4
   乾燥dried (MgSO4)
5. 5
   ろ過filtered
6. 6
   濃縮concentrated
7. 7
   その他to give an oil
8. 8
   その他This oil was taken on to the next step without further purification

実験手順

Methyl 3,5-dichloro-4-hydroxybenzoate, (173, 0.78 mol), 1-bromododecane (234 g, 0.94 mol) and potassium carbonate (130 g, 0.94 g) in DMF (1000 mL) were heated to 70° C. with good stirring for about 8 hrs. The reaction was cooled and treated with 2N-HCl to neutralize the excess potassium carbonate. The mixture was then extracted with ethyl acetate. The ethyl acetate was washed with 2N-HCl(×3), dried (MgSO4), filtered and concentrated to give an oil. This oil was taken on to the next step without further purification.

出典