反応 #565292

反応方程式

hydrogen

aniline

2-heptanone

4-toluene sulphonic acid

→

N-(1methylhexyl)aniline

収率 37.0%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他The cooled reaction mixture
2. 2
   ろ過filtered
3. 3
   洗浄washed with 1N-hydrochloric acid (6×200 parts) and water (2×200 parts)
4. 4
   その他the ethyl acetate was separated
5. 5
   乾燥dried (MgSO4)
6. 6
   その他before evaporating

実験手順

A mixture of aniline (100 parts), 2-heptanone (220 parts), 4-toluene sulphonic acid (6 parts) and 3% palladium on carbon (5 parts) in a 1 litre autoclave was charged with hydrogen to a pressure of 80 atmospheres and heated at 150° C. for 40 hours. The cooled reaction mixture was diluted with ethyl acetate, filtered, washed with 1N-hydrochloric acid (6×200 parts) and water (2×200 parts), the ethyl acetate was separated and dried (MgSO4) before evaporating to leave N-(1methylhexyl)aniline (76 parts, 37%).

出典