反応 #5648

反応方程式

tribromide

1,3,5-trisbromomethyl benzene

nitronium tetrafluoroborate

water

→

nitro

収率 86.4%

2,4,6-Tris(bromomethyl)nitrobenzene

収率 86.4%

溶媒

CH3CN

CH3CN

反応条件

後処理

1. 1
   抽出the mixture extracted with CH2Cl2
2. 2
   洗浄The CH2Cl2 extracts were washed with 10% NaHCO3
3. 3
   乾燥dried (Na2SO4) and solvents
4. 4
   その他removed

実験手順

To a solution of 5 g (0.014 mole) of the tribromide 8 in 100 ml of CH3CN was added, at room temperature and under argon atmosphere, in a dropwise fashion 3.72 g (0.028 mole) of nitronium tetrafluoroborate in 200 ml of CH3CN. The solution was then stirred for 20 minutes longer, poured into water and the mixture extracted with CH2Cl2. The CH2Cl2 extracts were washed with 10% NaHCO3, dried (Na2SO4) and solvents removed to afford 4.86 g (86%) of the desired nitro compound 27: NMR (CDCl3) 4.5 (s,6,--CH2Br), 7.55 (s,--C6H2).

出典