反応 #564152

反応方程式

2,2-difluoro-1,3-benzodioxole

methyl acetoacetate

acetic anhydride

→

Methyl (2,2-difluoro-1,3-benzodioxol-5-yl)-methyleneacetoacetate

反応条件

後処理

1. 1
   workup.WAITafter brief warming, the mixture is left
2. 2
   その他hydrolyzed with 1 l of ice-water and the oil which has separated out
3. 3
   その他is separated off
4. 4
   workup.ADDITIONdiluted with a little methylene chloride
5. 5
   その他dried

実験手順

50 mmol of 5-butyliminomethyl)-2,2-difluoro-1,3-benzodioxole and 50 mmol of methyl acetoacetate are added simultaneously to 80 ml of acetic anhydride and, after brief warming, the mixture is left to stand at room temperature for 24 hours. It is then hydrolyzed with 1 l of ice-water and the oil which has separated out is separated off, diluted with a little methylene chloride, dried and subsequently used as the crude product.

出典