反応 #56405

反応方程式

4-methylbenzenesulfonic acid

ethyl 4-oxo-1-piperidinecarboxylate

4-chlorobenzenamine

methylbenzene

→

ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate

溶媒

water

反応条件

後処理

1. 1
   温度refluxed for 7 hours
2. 2
   その他(The reaction vessel is provided with
3. 3
   温度a reflux-condensor
4. 4
   その他The methylbenzene is evaporated
5. 5
   workup.DISTILLATIONthe oily residue is distilled in vacuo

実験手順

A mixture of 171.2 parts of ethyl 4-oxo-1-piperidinecarboxylate, 159.5 parts of 4-chlorobenzenamine, 1520 parts of anhydrous methylbenzene and a few crystals of 4-methylbenzenesulfonic acid is stirred and refluxed for 7 hours. (The reaction vessel is provided with a reflux-condensor and water-separator). The methylbenzene is evaporated and the oily residue is distilled in vacuo, yielding 192 parts of oily ethyl 4-[(4-chlorophenyl)imino]-1-piperidinecarboxylate; bp. 171°-176° C. at 0.4 mm. pressure.

出典