反応 #56375

反応方程式

3-(2,2,2-trifluoroethoxy)-2,2-dimethylcyclopropanecarboxylic acid

potassium carbonate

4-fluoro-3-phenoxybenzyl bromide

→

4-fluoro-3-phenoxybenzyl 3-(2,2,2-trifluoroethoxy)-2,2-dimethylcyclopropanecarboxylate

溶媒

DMF

反応条件

後処理

1. 1
   抽出The reaction mixture is extracted with ether
2. 2
   洗浄the ether phase is washed with water (3×) and brine
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他The solvent is then removed

実験手順

To 10 ml DMF is added 0.88 g 3-(2,2,2-trifluoroethoxy)-2,2-dimethylcyclopropanecarboxylic acid (4.14 mmol) and 1.146 g potassium carbonate (8.29 mmol), after which is added 1.2 g 4-fluoro-3-phenoxybenzyl bromide. This mixture is stirred under nitrogen for 15 hours. The reaction mixture is extracted with ether and the ether phase is washed with water (3×) and brine, and dried over sodium sulfate. The solvent is then removed to yield 4-fluoro-3-phenoxybenzyl 3-(2,2,2-trifluoroethoxy)-2,2-dimethylcyclopropanecarboxylate.

出典