反応 #56328

反応方程式

5-amino-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide

chloroform

acetic anhydride

→

desired product

5-Amino-N-[(4-methoxy-6-methylpyrimidin-2-yl)amino-carbonyl]-2-methylbenzenesulfonamide

5-acetamido-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide

反応条件

後処理

1. 1
   workup.ADDITIONis added
2. 2
   温度The resulting mixture is then refluxed for 2 hours
3. 3
   その他the chloroform, excess acetic anhydride and acetic acid are removed in vacuo

実験手順

To a solution of 37.3 g of 5-amino-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide prepared in a minimum amount of boiling chloroform, is added with vigorous stirring 20.4 g of acetic anhydride. The resulting mixture is then refluxed for 2 hours, the chloroform, excess acetic anhydride and acetic acid are removed in vacuo to yield as residue the desired product, 5-acetamido-2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]benzenesulfonamide.

出典