反応 #56315

反応方程式

2-Methoxyaniline

sodium carbonate

2-Bromomethyl-4-ethyl-1,3-dioxolane

→

N-(4-ethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline

反応条件

後処理

1. 1
   その他equipped with a mechanical stirrer
2. 2
   温度thermometer and reflux condenser
3. 3
   温度the reaction mixture is heated
4. 4
   温度at reflux for a period of about 1 hour
5. 5
   ろ過After this time the reaction mixture is filtered
6. 6
   workup.ADDITIONadditional sodium carbonate (5 grams) is added to the filtrate
7. 7
   workup.DISTILLATIONThe mixture is then distilled under reduced pressure

実験手順

2-Methoxyaniline (0.5 mole) and sodium carbonate (30 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Bromomethyl-4-ethyl-1,3-dioxolane (0.55 mole) is slowly added and the reaction mixture is heated at reflux for a period of about 1 hour. After this time the reaction mixture is filtered and additional sodium carbonate (5 grams) is added to the filtrate. The mixture is then distilled under reduced pressure to yield the desired product N-(4-ethyl-1,3-dioxolan-2-ylmethyl)-2-methoxyaniline.

出典