反応 #56260

反応方程式

adenosine-5'-carboxylic acid methyl ester

tert.-butylamine

→

adenosine-5'-carboxylic acid N-tert.-butylamide

収率 38.0%

反応条件

後処理

1. 1
   その他is obtained
2. 2
   workup.WAITthe reaction mixture is left
3. 3
   workup.DISTILLATIONExcess tert.-butylamine is then distilled off
4. 4
   workup.ADDITIONthe residue is mixed with methanol
5. 5
   その他again evaporated to dryness
6. 6
   ろ過is filtered off with suction
7. 7
   その他After recrystallizing twice from a little methanol, there

実験手順

5 g of adenosine-5'-carboxylic acid methyl ester are heated together with 100 ml of tert.-butylamine on a streambath until a clear solution is obtained and thereafter the reaction mixture is left to stand for 16 hours at ambient temperature. Excess tert.-butylamine is then distilled off and the residue is mixed with methanol, again evaporated to dryness and the solid residue, after slurrying in cold methanol is filtered off with suction. After recrystallizing twice from a little methanol, there are obtained 2.15 g (38% of theory) of adenosine-5'-carboxylic acid N-tert.-butylamide, which melts, with decomposition, at 279°-280° C.

出典