反応 #56257

反応方程式

adenosine-5'-carboxylic acid methyl ester

triethylamine

→

Adenosine-5'-carboxylic acid benzyl ester

溶媒

benzyl alcohol

反応条件

後処理

1. 1
   その他After termination of the reaction
2. 2
   その他the residue is triturated with ether for the removal of traces of amine and solvent
3. 3
   ろ過after filtering off with suction
4. 4
   その他the product is recrystallized from water

実験手順

5 g of adenosine-5'-carboxylic acid methyl ester are suspended in 200 ml of benzyl alcohol, with the addition of 7 g of triethylamine, and the reaction mixture heated to 100° C. for 5 hours, the methyl ester thereby going into solution. After termination of the reaction, the base and excess alcohol are stripped off in a vacuum, the residue is triturated with ether for the removal of traces of amine and solvent and, after filtering off with suction, the product is recrystallized from water. There are thus obtained 3.3 g (53% of theory) of adenosine-5'-carboxylic acid benzyl ester, which has a melting point of 144°-145° C.

出典