反応 #56244

反応方程式

3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid

sodium acetate

→

product

sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylate

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   ろ過The solution was filtered

実験手順

15 g of the syn isomer of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid were dissolved at -15° C. in a solution of 5 g of sodium acetate in 100 ml of methanol and 3 g of activated carbon were added thereto. The solution was filtered and the filtrate was heated to 20° C. to obtain crystals of a methanol solvate of the syn isomer of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylate identical to the product of Step A of Example 1.

出典