反応 #56223

反応方程式

3-benzylpyrrolylmethyl methanesulfonate

2-(6-Chloro-2-benzothienyl)-3-methylbutanoic acid

→

3-benzylpyrrolylmethyl 2-(6-chloro-2-benzothienyl)-3-methylbutanoate

溶媒

THF DMF

THF DMF

ether

反応条件

後処理

1. 1
   洗浄washed with water (3×) and sat. NaCl
2. 2
   その他dried
3. 3
   その他solvent is removed

実験手順

2-(6-Chloro-2-benzothienyl)-3-methylbutanoic acid (3.40 mmol) is stirred together with 0.34 g (3.40 mmol) KHCO3 in 10 ml THF/DMF (1:1) for 15 minutes. Then 3.40 mmol of 3-benzylpyrrolylmethyl methanesulfonate in 5 ml THF/DMF (1:1) is added and the mixture stirred for approximately 48 hours. The reaction is diluted with ether, washed with water (3×) and sat. NaCl, dried and solvent is removed to yield 3-benzylpyrrolylmethyl 2-(6-chloro-2-benzothienyl)-3-methylbutanoate.

出典