反応 #56221

反応方程式

3-benzylpyrrolyl methanol

2-(5-fluoro-2-benzothienyl)-3-methylbutanoic acid

N,N'-dicyclohexylcarbodiimide

→

3-benzylpyrrolylmethyl 2-(5-fluoro-2-benzothienyl)-3-methylbutanoate

溶媒

methylene chloride

DMF

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   抽出extracted with water
3. 3
   抽出The aqueous phase is extracted with ether
4. 4
   洗浄The combined organic phases are washed with saturated aqueous NaHCO3, water and saturated aqueous NaCl
5. 5
   乾燥dried over CaSO4 and solvent
6. 6
   その他evaporated

実験手順

To a stirred solution of 3-benzylpyrrolyl methanol (1.8 mmol), 2-(5-fluoro-2-benzothienyl)-3-methylbutanoic acid (2.0 mmol) and 4-dimethylaminopyridine (2.0 mmol) in 20 ml of methylene chloride and 2 ml of DMF is added N,N'-dicyclohexylcarbodiimide (2.0 mml). The reaction mixture is stirred, under nitrogen, for about two hours and then filtered and extracted with water. The aqueous phase is extracted with ether. The combined organic phases are washed with saturated aqueous NaHCO3, water and saturated aqueous NaCl, dried over CaSO4 and solvent evaporated to yield 3-benzylpyrrolylmethyl 2-(5-fluoro-2-benzothienyl)-3-methylbutanoate.

出典