反応 #56220

反応方程式

3-benzylpyrrolylmethyl alcohol

triethylamine

2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid

→

3-benzylpyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

溶媒

ether

反応条件

後処理

1. 1
   その他quenched with saturated aqueous NaHCO3
2. 2
   洗浄The ether phase is washed with aqueous NaHCO3, water and brine
3. 3
   乾燥dried over sodium sulfate and solvent
4. 4
   その他evaporated

実験手順

To a stirred solution of 3-benzylpyrrolylmethyl alcohol (0.99 mmol) and triethylamine (0.14 g, 1.38 mmol) in ether (about15 ml), under nitrogen, is added a solution of the acid chloride of 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (1.5 mmol) in either. The mixture is stirred for about 60 minutes and then quenched with saturated aqueous NaHCO3. The ether phase is washed with aqueous NaHCO3, water and brine, dried over sodium sulfate and solvent evaporated to give 3-benzylpyrrolylmethyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

出典