反応 #56208

反応方程式

methylene chloride

2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid

K2CO3

α-cyano-3-phenoxybenzyl chloride

→

α-cyano-3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

溶媒

DMSO

ether

THF

反応条件

後処理

1. 1
   その他reaction mixture
2. 2
   workup.STIRRINGstirred for about 48 hours
3. 3
   洗浄washed with water and brine
4. 4
   乾燥dried over Na2SO4 and solvent
5. 5
   その他removed

実験手順

A mixture of 10 ml methylene chloride, 10 ml THF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.25 g) and α-cyano-3-phenoxybenzyl chloride (0.42 g) is stirred at RT for 15 hours. Then 5 ml of DMSO is added and reaction mixture stirred for about 48 hours. The mixture is taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ethyl acetate/hexane to give α-cyano-3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

出典