反応 #561836

反応方程式

ethyl trifluoroacetate

1,3-diamino-2-propanol

→

title compound

収率 97.5%

2-(trifluoromethyl)-1,4,5,6-tetrahydro-5-pyrimidinol

収率 97.5%

溶媒

p-Xylene

反応条件

後処理

1. 1
   濃縮Concentration in vacuo

実験手順

To a solution of ethyl trifluoroacetate (5.80 g, 40.8 mmol) in p-Xylene (30 mL) was added 1,3-diamino-2-propanol (3.60 g, 40 mmol). The mixture was stirred at 160° C. for 4 h. Concentration in vacuo then afforded the title compound (6.55 g, 39.0 mmol, 97% yield).

出典