反応 #56135

反応方程式

propargyl alcohol

phosphorus trichloride

9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid

pyridine

→

9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid propargyl ester

溶媒

water

tetrahydrofuran

反応条件

後処理

1. 1
   温度cooled to 0° C.
2. 2
   その他dropwise at 0°-5° C.
3. 3
   workup.STIRRINGThe mixture is stirred for 2 hours at room temperature
4. 4
   洗浄The organic phase is washed successively with water, dilute hydrochloric acid
5. 5
   乾燥a 2% aqueous sodium bicarbonate solution, dried over sodium sulphate
6. 6
   その他evaporated

実験手順

20 g of 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid are dissolved in 200 ml of tetrahydrofuran. After the addition of 5.5 ml of phosphorus trichloride, the solution is stirred for 2 hours at room temperature, cooled to 0° C. and treated firstly with 50 ml of pyridine and then dropwise at 0°-5° C. with 50 ml of propargyl alcohol. The mixture is stirred for 2 hours at room temperature and then diluted with water. The organic phase is washed successively with water, dilute hydrochloric acid and a 2% aqueous sodium bicarbonate solution, dried over sodium sulphate and evaporated. There is obtained 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraen-1-oic acid propargyl ester which melts at 94°-95° C. after absorption on aluminium oxide using benzene as the eluent.

出典