反応 #5610

反応方程式

5-benzyloxy-2-vinyl-4-pyridone

pyrrolidine

→

5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

溶媒

tetrahydrofuran

diisopropyl ether

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度refluxed for an hour
3. 3
   温度The mixture was cooled
4. 4
   ろ過the resulting precipitate was collected by filtration
5. 5
   洗浄washed with diisopropyl ether
6. 6
   その他air-dried at ambient temperature

実験手順

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

出典