反応 #5604
ord-e8381d73f4f9423dbff70d4f1bb4f249
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度maintaining the temperature below 30° C
- 2その他to precipitate pyrrolidinium bromide, which
- 3その他was separated by filtration
- 4その他The filtrate was evaporated under vacuum
- 5その他to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate
実験手順
To an ice bath-cooled solution of 213.4 g (3 mol) of pyrrolidine in 450 mL of tetrahydrofuran was added dropwise over about 2 hours 250.5 g (1.5 mol) of ethyl bromoacetate, maintaining the temperature below 30° C. To this solution was added 150 mL of toluene to precipitate pyrrolidinium bromide, which was separated by filtration. The filtrate was evaporated under vacuum to provide a residue of about 241 g of ethyl 1-pyrrolinidineacetate.