反応 #56010

反応方程式

malonic acid

diethanol amine

benzaldehyde

→

Bis-(hydroxyethyl)amino benzyl malonic acid

溶媒

methanol

反応条件

後処理

1. 1
   その他equipped with a stirrer
2. 2
   温度reflux condenser
3. 3
   その他the reaction commenced
4. 4
   温度After refluxing the reaction mixture for 1 hour
5. 5
   その他the methanol was removed from the reaction mixture
6. 6
   温度heating to a temperature of about 50° C
7. 7
   その他then was triturated in acetone
8. 8
   その他the resulting acid isolated by filtration

実験手順

Bis-(hydroxyethyl)amino benzyl malonic acid was prepared conventionally in a flask equipped with a stirrer and reflux condenser by first charging 0.1 mol of malonic acid, 0.1 mol of diethanol amine and 100 cc methanol. The contents were warmed to a temperature of about 20° C. and then 0.1 mol benzaldehyde were added to the flask and the reaction commenced. After refluxing the reaction mixture for 1 hour, the methanol was removed from the reaction mixture by coupling the flask to a vacuum source and heating to a temperature of about 50° C. The residue remaining in the flask then was triturated in acetone and the resulting acid isolated by filtration.

出典