反応 #55922

反応方程式

3-bromo-4 octyloxybenzoic acid chloride

H2SO4

→

product

3-bromo 4-octyloxy benzoic acid

溶媒

pyridine

反応条件

後処理

1. 1
   workup.ADDITIONThe reaction mixture is then poured into a solution
2. 2
   抽出The organic fraction is extracted three times with ether
3. 3
   洗浄then washed three times with water
4. 4
   乾燥finally dried on anhydrous Na2SO4
5. 5
   その他The solvent is evaporated
6. 6
   その他the product is recrystallised three times in ethanol

実験手順

540 mg (≃0.002 mole) of ##STR17## C5H11 and 700 mg (≃0.002 mole) of 3-bromo-4 octyloxybenzoic acid chloride are charged in a reactor containing 10 ml of pyridine and kept at ambient temperature for 48 hours. The reaction mixture is then poured into a solution containing 10 ml of concentrated H2SO4 and 100 g of ice. The organic fraction is extracted three times with ether then washed three times with water and finally dried on anhydrous Na2SO4. The solvent is evaporated and the product is recrystallised three times in ethanol. 850 ml of product are obtained. The molar efficiency is 73%. Step (d) of substituting the cyanide group for the bromine group

出典