反応 #55866

反応方程式

9-(1-Hydroxy-2-propyl)-6-chloropurine

hydroiodic acid

→

9-(1-HYDROXY-2-PROPYL)-6-IODOPURINE

溶媒

H2O

反応条件

後処理

1. 1
   ろ過The precipitate was filtered
2. 2
   その他neutralized with anhydrous sodium acetate at 5°
3. 3
   洗浄washed with a little cold water (3 times)
4. 4
   その他Recrystallization from ethanol/H2O
5. 5
   その他gave colorless crystals

実験手順

9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%) mp=193°-194°; uv λmax 276 nm (H2O, pH 5.5).

出典