反応 #558625

反応方程式

3-Methyl-1,3-butanediol

pyridine

4-toluenesulfonyl chloride

→

title compound

Toluene-4-sulfonic acid 3-hydroxy-3-methyl-butyl ester

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄then washed with 1M aqueous hydrochloric acid
2. 2
   その他dried
3. 3
   その他the solvent removed under vacuum
4. 4
   その他The residue is purified by flash chromatography (0-30% ethyl acetate in cyclohexane)

実験手順

3-Methyl-1,3-butanediol (1.5 mL, 14.06 mmol) is suspended in dry dichloromethane (5 mL) and pyridine (1.24 mL, 15.46 mmol) is added followed by 4-toluenesulfonyl chloride (2.68 g, 14.06 mmol). The mixture is stirred overnight then washed with 1M aqueous hydrochloric acid, dried and the solvent removed under vacuum. The residue is purified by flash chromatography (0-30% ethyl acetate in cyclohexane) to give the title compound. (Yield 970 mg).

出典