反応 #5585

反応方程式

ethanol

sodium mercaptoethansulphonate

mercaptoethansulphonic acid

arginine

→

white crystalline product

収率 98.0%

arginine mercaptoethansulphonate

収率 98.0%

溶媒

water

反応条件

後処理

1. 1
   濃縮The solution is then concentrated to dryness
2. 2
   その他giving a residue which
3. 3
   workup.STIRRINGThe suspension is agitated at 50° C. for 30 minutes
4. 4
   温度cooled
5. 5
   ろ過filtered

実験手順

12 g of sodium mercaptoethansulphonate are freed in aqueous solution and under nitrogen stream in a column, as described in the example 1. The mercaptoethansulphonic acid coming out of the column in aqueous solution, under nitrogen stream and at pH=1, is gradually added with arginine, in free base form, in stoichiometrical amount dissolved in water under nitrogen stream (12.7 g), by operating at pH values of between 6 and 7. Upon the salification is completed the pH of the solution of the salt must be of between 6 and 7. The solution is then concentrated to dryness giving a residue which, upon being taken with 200 ml of absolute ethanol, under stirring and in hot condition, is converted into white crystals. The suspension is agitated at 50° C. for 30 minutes, then cooled and filtered, whereby 22.8 g of white crystalline product are obtained, with a 98% yield and a melting point of 214°-216° C.; the pH in 10% aqueous solution is 6.7 and the solubility in water is perfect. The analysis gave the following results:

出典