反応 #5577

反応方程式

5-[2-(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride

→

desired product

収率 99.7%

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

収率 99.7%

溶媒

chloroform

反応条件

後処理

1. 1
   洗浄was washed with 3N sodium hydroxide (50 ml)
2. 2
   抽出the aqueous layer was extracted with chloroform
3. 3
   乾燥the combined chloroform layer was dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThen, the solvent was distilled off

実験手順

After a suspension of 5-[2-(amino)ethylthio]imidazo-[1,2-a]pyridine dihydrochloride (13.31 g, 50 mmloes) in chloroform (200 ml) was washed with 3N sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, the combined chloroform layer was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

出典