反応 #5575

反応方程式

5-(2-hydroxy)ethylthioimidazo[1,2-a]pyridine

triethylamine

methanesulfonyl chloride

→

desired product

収率 99.9%

5-[2-(methylsulfonyloxy)ethylthio]imidazo[1,2-a]pyridine

収率 99.9%

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGthe mixture was stirred under ice-
3. 3
   温度cooling for 2 hours
4. 4
   洗浄The reaction mixture was washed in turn with aqueous saturated sodium bicarbonate and saturated saline
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThen, the solvent was distilled off

実験手順

To a solution of 5-(2-hydroxy)ethylthioimidazo[1,2-a]pyridine (9.71 g, 50 mmoles) and triethylamine (10.5 ml, 75.3 mmoles) in methylene chloride (300 ml) was added methanesulfonyl chloride (4.26 ml, 55 mmoles) under ice-cooling with stirring and the mixture was stirred under ice-cooling for 2 hours. The reaction mixture was washed in turn with aqueous saturated sodium bicarbonate and saturated saline and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off to obtain 13.6 g of the desired product (quantitative, brown oily product).

出典