反応 #55745

反応方程式

2-ethoxy-4-amino-benzoic acid ethyl ester

5-chloro-2-methoxy-benzoyl chloride

→

2-ethoxy-4-(5-chloro-2-methoxy-benzamido)-benzoic acid ethyl ester

溶媒

triethylamine

toluene

toluene

反応条件

後処理

1. 1
   workup.ADDITIONwere added dropwise
2. 2
   温度under reflux
3. 3
   温度after cooling
4. 4
   洗浄it was washed with water, dilute hydrochloric acid
5. 5
   乾燥a sodium bicarbonate solution and dried over sodium sulfate

実験手順

10.4 g of 2-ethoxy-4-amino-benzoic acid ethyl ester were suspended in a mixture of 6.8 ml of triethylamine and 200 ml of toluene and 10.3 g of 5-chloro-2-methoxy-benzoyl chloride dissolved in a small amount of toluene were added dropwise. The whole was stirred for 3 hours under reflux and, after cooling, it was washed with water, dilute hydrochloric acid and a sodium bicarbonate solution and dried over sodium sulfate. Upon concentration of the solution under reduced pressure, the 2-ethoxy-4-(5-chloro-2-methoxy-benzamido)-benzoic acid ethyl ester was obtained in the form of a solid product having a crude melting point of 108°-111° C.

出典