反応 #557437

反応方程式

Benzyl(4aR,7aR)-2-(benzoylamino)-7a-(5-bromothiophen-2-yl)-4a,5,7,7a-tetrahydropyrrolo[3,4-d][1,3]thiazine-6(4H)-carboxylate

1-butylimidazole

toluene

→

title compound

収率 74.0%

Benzyl(4aR,7aR)-2-(benzoylamino)-7a-(5-cyanothiophen-2-yl)-4a,5,7,7a-tetrahydropyrrolo[3,4-d][1,3]thiazine-6(4H)-carboxylate

収率 74.0%

溶媒

ethyl acetate

water

反応条件

後処理

1. 1
   その他fitted with a stirrer bar
2. 2
   workup.WAITA stream of nitrogen is passed over the mixture for a few minutes
3. 3
   その他the pressure tube is then sealed
4. 4
   温度The resulting dark mixture is cooled to room temperature
5. 5
   ろ過filtered through a pad of diatomaceous earth
6. 6
   洗浄while rinsing with ethyl acetate (100 mL) and water (15 mL)
7. 7
   その他The layers of the filtrate are separated
8. 8
   洗浄the organic layer is further washed with water (2×30 mL) and brine (30 mL)
9. 9
   乾燥The organic phase is dried over sodium sulfate
10. 10
    ろ過filtered
11. 11
    濃縮concentrated under reduced pressure
12. 12
    その他The residue is purified by silica gel flash chromatography
13. 13
    洗浄eluting with a hexanes/ethyl acetate, gradient from 80:20 to 0:100

実験手順

Benzyl(4aR,7aR)-2-(benzoylamino)-7a-(5-bromothiophen-2-yl)-4a,5,7,7a-tetrahydropyrrolo[3,4-d][1,3]thiazine-6(4H)-carboxylate (3.88 g, 6.97 mmol), anhydrous potassium hexacyanoferrate (II) (2.57 g, 6.97 mmol) (prepared as cited in Schareina, T.; et al Synthesis, 2008, 20, 3351-3355), copper (I) iodide (398 mg, 2.09 mmol), 1-butylimidazole (2.8 mL, 20.9 mmol), and toluene (23 mL) are added to a 60 mL glass pressure tube fitted with a stirrer bar. A stream of nitrogen is passed over the mixture for a few minutes and the pressure tube is then sealed. The stirred mixture is heated at 145° C. for 18 hours. The resulting dark mixture is cooled to room temperature. The mixture is diluted with ethyl acetate (100 mL) and water (15 mL) and vacuum filtered through a pad of diatomaceous earth while rinsing with ethyl acetate (100 mL) and water (15 mL). The layers of the filtrate are separated and the organic layer is further washed with water (2×30 mL) and brine (30 mL). The organic phase is dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue is purified by silica gel flash chromatography eluting with a hexanes/ethyl acetate, gradient from 80:20 to 0:100, to give the title compound (2.59 g, 74%) as a white foam: ES/MS (m/z): 503.2 (M+H).

出典