反応 #55741

反応方程式

2-ethoxy-5-chloro-benzoylchloride

4-(2-aminoethyl)-benzoic acid hydrochloride

→

benzoic acid

溶媒

acetone

water

acetone

sodium hydroxide

反応条件

後処理

1. 1
   workup.STIRRINGStirring
2. 2
   ろ過filtered
3. 3
   ろ過After filtration with suction
4. 4
   その他the product was recrystallized from ethanol

実験手順

10 g of 4-(2-aminoethyl)-benzoic acid hydrochloride were dissolved in 60 ml of 2 N-sodium hydroxide solution and, after addition of 75 ml of acetone, a solution of 11 g of 2-ethoxy-5-chloro-benzoylchloride in 20 ml of acetone was added dropwise, while stirring. Stirring was continued for 2 hours, the mixture was diluted with water, filtered and acidified with dilute hydrochloric acid. After filtration with suction, the product was recrystallized from ethanol. The 4-(2-<2-ethoxy-5-chloro-benzamido>-ethyl)-benzoic acid obtained was found to melt at 180° C.

出典