反応 #55739

反応方程式

4-(2-acetylaminoethyl)-benzoic acid

sodium hydroxide

hydrochloric acid

4-(2-aminoethyl)-benzoic acid sodium

sodium acetate

3-chlorobenzyl chloride

→

benzoic acid

溶媒

acetone

acetone

water

反応条件

後処理

1. 1
   ろ過filtered off with suction
2. 2
   その他the product was recrystallized from a mixture of water and isopropanol

実験手順

50 ml of a 1-molar solution of 4-(2-aminoethyl)-benzoic acid-sodium, which contained, in addition, 0.05 mole of sodium acetate and which had been prepared by saponification of 4-(2-acetylaminoethyl)-benzoic acid with sodium hydroxide solution, was combined with 50 ml of acetone and then with the solution of 9 g of 3-chlorobenzyl chloride in a small amount of acetone. The whole was stirred for about 1 hour, water and hydrochloric acid were added, filtered off with suction and the product was recrystallized from a mixture of water and isopropanol. The 4-(2-<3-chloro-benzamido>-ethyl)-benzoic acid obtained was found to melt at 200° to 202° C.

出典