反応 #55704

反応方程式

4-chlorobenzyl cyanide

caprolactim methyl ether

diazabicyclo [5.4.0]undec-5-ene

→

title compound

収率 67.6%

2-(α-cyano-4-chlorobenzylidene)perhydroazepine

収率 67.6%

溶媒

methyl alcohol

反応条件

後処理

1. 1
   温度Cool
2. 2
   その他the thus-obtained reaction mixture to ambient temperature
3. 3
   ろ過before filtering

実験手順

Agitate a mixture of 5.0 g of 4-chlorobenzyl cyanide, 5.5 g of caprolactim methyl ether and 0.5 g of diazabicyclo [5.4.0]undec-5-ene under nitrogen for 18 hours at 125°. Cool the thus-obtained reaction mixture to ambient temperature and then rub down the crystallizing residue with 20 ml of methyl alcohol before filtering to obtain 5.5 g of the title compound. Recrystallize this compound from methyl alcohol to obtain a product with a MP of 114° to 117°.

出典