反応 #55687

反応方程式

1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone

n-butylamine

→

N-n-butyl-alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide

収率 85.0%

溶媒

methanol

反応条件

後処理

1. 1
   温度The reaction mixture is heated
2. 2
   その他evaporated under a high vacuum

実験手順

10.14 g (0.06 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are dissolved in 50 ml of methanol and 8.78 g (0.12 mol) of n-butylamine are added to the solution. The reaction mixture is heated under reflux (65° C.) for 3 hours and then evaporated under a high vacuum. 12.3 g (yield: 85% of theory) of N-n-butyl-alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide are obtained in the form of a syrup.

出典