反応 #55661

反応方程式

Bis(methylthio)methylenemalononitrile

2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamine

→

title compound

1,1-Dicyano-2-methylthio-2-{2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene

溶媒

ethanol

反応条件

後処理

1. 1
   workup.ADDITION, 95, 2861 (1962)] (9.94 g, 58.4 mmole) was added
2. 2
   その他the solvent was removed by evaporation under reduced pressure
3. 3
   その他chromatographed

実験手順

Bis(methylthio)methylenemalononitrile [prepared according to the procedure described in Chem. Ber., 95, 2861 (1962)] (9.94 g, 58.4 mmole) was added with stirring to a solution of 2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamine (10.0 g, 58.4 mmole) in 100 ml of absolute ethanol. After stirring at room temperature for 90 minutes, the solvent was removed by evaporation under reduced pressure, and the residue placed on silica gel and chromatographed to yield the title compound (15.65 g).

出典