反応 #55619

反応方程式

3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione

dimethylamine

→

o-(5-isopropyl-5-methyl-4-oxo-2-imidazolin-2-yl)-N,N-dimethylbenzamide

収率 91.3%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他The bottle is sealed
2. 2
   温度The mixture is cooled
3. 3
   その他the contents of the bottle transferred to a flask
4. 4
   その他The solvent is then removed in vacuo
5. 5
   ろ過filtered
6. 6
   洗浄washed with ether

実験手順

To a cold solution of 180 g of 3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione in 300 ml of dry tetrahydrofuran in a pressure bottle is added 68 g of dimethylamine. The bottle is sealed and the mixture heated to 50° C. with stirring for 16 hours. The mixture is cooled, and the contents of the bottle transferred to a flask. The solvent is then removed in vacuo. The crystalline residue is then suspended in ether, filtered, washed with ether, and airdried to give 195 g of o-(5-isopropyl-5-methyl-4-oxo-2-imidazolin-2-yl)-N,N-dimethylbenzamide, melting point 144°-146° C. This product is recrystallized from acetonitrile to give an analytically pure product, melting point 147°-150° C.

出典