反応 #55595

反応方程式

m-Fluorobenzonitrile

sulfuric acid

potassium nitrate

→

3-cyano-4-nitrofluorobenzene

収率 86.5%

溶媒

反応条件

後処理

1. 1
   抽出extracted with chloroform (5×250 ml.)
2. 2
   その他dried
3. 3
   その他the solvent removed
4. 4
   抽出The residue is extracted with pentane
5. 5
   その他dried

実験手順

m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3°-6° C., then allowed to warm to 25° C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5×250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102°-104° C.

出典