反応 #55566

反応方程式

9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid, methyl ester

NaOH

→

9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid

収率 91.5%

溶媒

water

methanol

water

反応条件

後処理

1. 1
   抽出extracted with diethyl ether (10 ml)
2. 2
   抽出extracted with diethyl ether (3×15 ml)
3. 3
   洗浄The ethereal solution is washed with water to neutrality
4. 4
   乾燥dried over sodium sulphate
5. 5
   その他the solvent evaporated in vacuo

実験手順

The solution of 0.5 g of 9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid, methyl ester, 0.170 g of NaOH in water (1.5 ml), methanol (4.5 ml) is left for two hours at room temperature under nitrogen, then diluted with water (22 ml) and extracted with diethyl ether (10 ml). The aqueous layer is acidified (congo red) with HCl (5%), then extracted with diethyl ether (3×15 ml). The ethereal solution is washed with water to neutrality, dried over sodium sulphate and the solvent evaporated in vacuo to yield 0.44 g of 9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid (oil).

出典