反応 #5556

反応方程式

benzenesulfonyl chloride

5-[3-(amino)propyloxy]imidazo[1,2-a]pyridine dihydrochloride

triethylamine

acetonitrile

→

desired product

収率 59.5%

5-[3-(benzenesulfonamido)propyloxy]imidazo[1,2-a]pyridine

収率 59.5%

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hour
3. 3
   洗浄The reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and saturated saline
4. 4
   乾燥dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONAfter the solvent was distilled off
6. 6
   その他the crude product thus obtained
7. 7
   その他was recrystallized from methylene-ethanol

実験手順

To a suspension of 5-[3-(amino)propyloxy]imidazo[1,2-a]pyridine dihydrochloride (2.64 g, 10 mmoles) and triethylamine (4.88 ml, 35 mmoles) in methylene chloride (100 ml)-acetonitrile (30 ml) was added benzenesulfonyl chloride (1.53 ml, 12 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 1 hour. The reaction mixture was washed in turn with an aqueous sodium bicarbonate solution and saturated saline and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the crude product thus obtained was recrystallized from methylene-ethanol to obtain 1.97 g of the desired product (59.5%, light brown crystals).

出典