反応 #55513

反応方程式

butyraldehyde

Formula IV

butyraldehyde

cyclohexylamine

Formula III

cyclohexylamine

sodium sulfate

→

1-BUTYLIDENE CYCLOHEXYLAMINE

収率 86.0%

反応条件

後処理

1. 1
   その他The product was decanted from the salt water slurry
2. 2
   乾燥dried by addition of further 10 g of anhydrous sodium sulfate
3. 3
   ろ過filtered
4. 4
   workup.DISTILLATIONdistilled

実験手順

At 0° C., 16.3 g (20 mL, 0.23 mol) of butyraldehyde (Formula IV) was added dropwise to 21.7 g (25 mL, 0.22 mol) of cyclohexylamine (Formula III). After 1 h, 6 g of anhydrous sodium sulfate was added and the mixture stirred for 5 h. The product was decanted from the salt water slurry, dried by addition of further 10 g of anhydrous sodium sulfate, filtered and distilled. Characteristics of the product: bp 88° C. (20 mm); yield 86%; NMR (CDCl3, δ): 1.0 (3H, t) 1.1-2.1 (12H), 2.3 (2H, g), 3.0 (1H, m), 7.8 (1H, t).

出典