反応 #55500

反応方程式

isopropylamine

cyanuric chloride

sodium hydroxide

→

2,4-dichloro-6-isopropylamino-s-triazine

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他the organic phase is separated
2. 2
   洗浄washed with two 100 ml portions of water
3. 3
   乾燥dried over sodium sulphate
4. 4
   その他The solvent is evaporated

実験手順

A suspension of 369 g of cyanuric chloride in 1000 ml of ethyl acetate is cooled to -15° C. With good stirring, 124 g of isopropylamine are first added dropwise at -20° C. to -10° C. in the course of 21/2 hours, followed by 267 g of a 30% aqueous solution of sodium hydroxide in the course of one hour. The reaction mixture is stirred for a further 11/2 hours at the same temperature, then the organic phase is separated, washed with two 100 ml portions of water and dried over sodium sulphate. The solvent is evaporated, to yield an oil from which the 2,4-dichloro-6-isopropylamino-s-triazine precipitates in crystalline form after stirring with petroleum ether at low temperature. Melting point: 46°-47° C.

出典