反応 #554701

反応方程式

benzyl piperazine-1-carboxylate

1,2-epoxycyclopentane

→

expected compound

収率 44.2%

Benzyl 4-(trans-2-hydroxycyclopentyl)piperazine-1-carboxylate

収率 44.2%

反応条件

後処理

1. 1
   濃縮The reaction mixture is concentrated under vacuum
2. 2
   その他the residue is purified by silica gel chromatography
3. 3
   洗浄eluting with EtOAc/MeOH mixture

実験手順

A solution of 0.524 g of benzyl piperazine-1-carboxylate is cooled to 0° C., 0.2 g of 1,2-epoxycyclopentane is added and it is heated at 80° C. for four days. The reaction mixture is concentrated under vacuum and the residue is purified by silica gel chromatography, eluting with EtOAc/MeOH mixture. 0.32 g of the expected compound is obtained.

出典