反応 #554624

反応方程式

N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

methylamine

→

2-(4-(Aminomethyl)benzyloxy)4-aminopyrimidine

溶媒

methanol

反応条件

後処理

1. 1
   その他all volatiles are removed in vacuo
2. 2
   その他The product is used without further purification in the next step

実験手順

150 mg (0.46 mmol) of N-(4-((4-Aminopyrimidin-2-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide (1) is dissolved in 2 mL methanol and treated with 5 mL methylamine (33% in ethanol). The reaction mixture is stirred at room temperature over night and all volatiles are removed in vacuo. The product is used without further purification in the next step. ESI-MS m/z 231 [M+H]+.

出典