反応 #55442

反応方程式

3,4-Dimethoxyphenethylamine

p-toluidinoacetic acid

→

N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(p-toluidino)acetamide

収率 71.4%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度After cooling
2. 2
   洗浄the solution was washed with a cooled 1 N sodium hydroxide solution and water
3. 3
   その他dried
4. 4
   workup.DISTILLATIONThe solvent was distilled off
5. 5
   その他the oily residue was crystallized
6. 6
   workup.ADDITIONby adding ether

実験手順

3,4-Dimethoxyphenethylamine (14.4 g ) and p-toluidinoacetic acid (13.1 g) were heated for 1.5 hours at 190° C. in a stream of nitrogen. After cooling, the reaction mixture was dissolved in ethyl acetate and the solution was washed with a cooled 1 N sodium hydroxide solution and water and then dried. The solvent was distilled off and the oily residue was crystallized by adding ether to give N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(p-toluidino)acetamide (18.6 g), mp 87° to 88.5° C.

出典