反応 #5543

反応方程式

5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine

3-aminopropanol

→

desired product

収率 55.6%

5-[2-[3-(hydroxy)propylcarbamoyloxy]ethylthio]imdazo[1,2-a]pyridine

収率 55.6%

溶媒

chloroform

反応条件

後処理

1. 1
   温度The reaction mixture was cooled
2. 2
   洗浄which was washed with water
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   その他Then, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20)

実験手順

To 5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine (1.10 g, 3.50 mmoles) was added 3-aminopropanol (0.27 ml, 3.52 mmoles) and the mixture was stirred at 120° C. for 1.5 hours. The reaction mixture was cooled by standing and chloroform was added thereto, which was washed with water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. Then, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20) to obtain 575 mg of the desired product (55.6%, colorless crystals).

出典