反応 #55414

反応方程式

sodium hydroxide

7-amino-3-[1-(2-carbamoylethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid

sodium bicarbonate

methylmercaptoacetyl chloride

→

title compound

7-Methylmercaptoacetamido-3-[1-(2-carbamoylethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid

溶媒

acetone

acetone

反応条件

後処理

1. 1
   温度To a stirred, cooled (-20°) solution of 10.2 g
2. 2
   workup.ADDITIONAfter addition the reaction mixture
3. 3
   温度is warmed to 25°
4. 4
   抽出extracted with ether
5. 5
   温度The remaining aqueous phase is cooled
6. 6
   workup.ADDITIONof ethyl acetate is added
7. 7
   その他The layers are separated
8. 8
   抽出the aqueous phase is extracted twice more with ethyl acetate
9. 9
   乾燥The combined extracts are dried (MgSO4)
10. 10
    その他evaporated to dryness

実験手順

To a stirred, cooled (-20°) solution of 10.2 g. (0.026 mol.) of 7-amino-3-[1-(2-carbamoylethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid in 220 ml. of 3% sodium bicarbonate and 220 ml. of acetone is dropwise added a solution of 3.66 g. (0.029 mol.) of methylmercaptoacetyl chloride in 52 ml. of acetone, during which time the pH of the reaction mixture is maintained at 8.0 by addition of 10% sodium hydroxide. After addition the reaction mixture is stirred an additional 20 minutes at -15°, then is warmed to 25° and extracted with ether. The remaining aqueous phase is cooled, 250 ml. of ethyl acetate is added and the slurry is acidified with 3N hydrochloric acid. The layers are separated and the aqueous phase is extracted twice more with ethyl acetate. The combined extracts are dried (MgSO4) and evaporated to dryness to yield the title compound.

出典