反応 #55411

反応方程式

7-amino-3-[1-(2-carbamoylethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid

dimethylformamide

trifluoromethylmercaptoacetic acid

→

title compound

7-Trifluoromethylmercaptoacetamido-3-[1-(2-carbamoylethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid

溶媒

triethylamine

反応条件

後処理

1. 1
   workup.ADDITIONA suspension of 3.85 g
2. 2
   その他The reaction mixture was evaporated to dryness and water and ethyl acetate
3. 3
   workup.ADDITIONwere added to the residue
4. 4
   その他The layers were separated
5. 5
   workup.ADDITIONethyl acetate was added to the aqueous phase and it
6. 6
   workup.ADDITIONwas acidified to pH 2.5 by addition of 6N hydrochloric acid
7. 7
   ろ過The mixture was filtered
8. 8
   その他the layers were separated
9. 9
   抽出the aqueous phase was extracted with ethyl acetate
10. 10
    洗浄The extract was washed with water
11. 11
    乾燥dried (MgSO4)
12. 12
    その他evaporated to dryness

実験手順

A suspension of 3.85 g. (0.01 mol.) of 7-amino-3-[1-(2-carbamoylethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid in 50 ml. of dry dimethylformamide was treated with 2 ml. of triethylamine and the mixture was stirred for 15 minutes at 25°. The activated ester of trifluoromethylmercaptoacetic acid (2.57 g., 0.016 mol.) was added to the mixture and it was stirred an additional hour. The reaction mixture was evaporated to dryness and water and ethyl acetate were added to the residue. The layers were separated, ethyl acetate was added to the aqueous phase and it was acidified to pH 2.5 by addition of 6N hydrochloric acid. The mixture was filtered, the layers were separated and the aqueous phase was extracted with ethyl acetate. The extract was washed with water, dried (MgSO4) and evaporated to dryness to give the title compound.

出典