反応 #5540

反応方程式

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

phthalic anhydride

→

desired product

収率 84.8%

5-[2-[2-(carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

収率 84.8%

溶媒

chloroform

反応条件

後処理

1. 1
   温度heated
2. 2
   温度at reflux for 5 hours
3. 3
   温度The reaction mixture was cooled
4. 4
   その他The crystals precipitated
5. 5
   ろ過were filtered off
6. 6
   洗浄washed with chloroform
7. 7
   その他dried

実験手順

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

出典