反応 #5537

反応方程式

5-[2-(methylsulfonylamino)ethylthio] imidazo[1,2-a]pyridine

formalin

morpholin

→

desired product

収率 71.5%

5-[2-(methylsulfonylamino)ethylthio]3-morpholinomethylimidazo[1,2-a]pyridine

収率 71.5%

溶媒

acetic acid

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 30 minutes
3. 3
   workup.STIRRINGby stirring at 60° C. for 2 hours
4. 4
   workup.DISTILLATIONAfter the solvent was distilled off
5. 5
   workup.DISSOLUTIONthe residue was dissolved in chloroform (50 ml)
6. 6
   洗浄washed with 1N NaOH (10 ml)
7. 7
   抽出Then, the aqueous layer was extracted with chloroform (30 ml×3)
8. 8
   乾燥the combined chloroform layer was dried over anhydrous magnesium sulfate
9. 9
   workup.DISTILLATIONthe solvent was distilled off
10. 10
    その他The residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:10→1:5)

実験手順

To a solution of 37% formalin (178 mg, 2.2 mmoles) in acetic acid (2 ml) was added morpholin (192 μl, 2.2 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 30 minutes. 5-[2-(methylsulfonylamino)ethylthio] imidazo[1,2-a]pyridine (543 mg, 2 mmoles) was added to the reaction mixture, followed by stirring at 60° C. for 2 hours. After the solvent was distilled off, the residue was dissolved in chloroform (50 ml) and washed with 1N NaOH (10 ml). Then, the aqueous layer was extracted with chloroform (30 ml×3) and the combined chloroform layer was dried over anhydrous magnesium sulfate, and then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:10→1:5) to obtain 530 mg of the desired product (71.5%, colorless solid).

出典