反応 #5536

反応方程式

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

triethylamine

ethanesulfonyl chloride

→

desired product

収率 78.2%

5-[2-(ethylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

収率 78.2%

溶媒

methylene chloride

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hour
2. 2
   洗浄The reaction mixture was washed in turn with an aqueous saturated sodium bicarbonate solution and water
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   その他The residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5)

実験手順

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.93 g, 10 mmoles) and triethylamine (1.53 ml, 11 mmoles) in methylene chloride (100 ml) was added ethanesulfonyl chloride (0.95 ml, 10 mmoles) at room temperature with stirring and the mixture was stirred at room temperature for 1 hour. The reaction mixture was washed in turn with an aqueous saturated sodium bicarbonate solution and water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:5) to obtain 2.23 g of the desired product (78.2%, colorless crystals).

出典