反応 #5534

反応方程式

water

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

triethylamine

methanesulfonyl chloride

→

desired product

収率 78.1%

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

収率 78.1%

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度cooling
2. 2
   workup.STIRRINGwas stirred under ice-
3. 3
   温度cooling for 1 hour
4. 4
   workup.STIRRINGstirred
5. 5
   その他Then, the crystals precipitated
6. 6
   ろ過were filtered off
7. 7
   洗浄washed with water
8. 8
   その他dried

実験手順

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (9.63 g, 49.8 mmoles) and triethylamine (7.64 ml) in methylene chloride (150 ml) was added methanesulfonyl chloride (3.85 ml, 49.7 mmoles) with stirring under ice-cooling and was stirred under ice-cooling for 1 hour. The reaction solution was poured into water and stirred. Then, the crystals precipitated were filtered off, washed with water and dried to obtain 10.53 g of the desired product (77.9%, colorless crystals).

出典