反応 #55336

反応方程式

2-(2-bromoethoxy)bibenzyl

4-piperidinecarboxamide

→

2-[2-(4-carbamoylpiperidino)ethoxy]bibenzyl

収率 82.3%

溶媒

tetrahydrofuran

water

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated and to the residue
2. 2
   workup.ADDITIONwas added 1 N NaOH aqueous solution
3. 3
   ろ過The resultant crystals were filtered
4. 4
   洗浄washed well with water
5. 5
   その他recrystallized from ethanol

実験手順

A solution of 2 g of 2-(2-bromoethoxy)bibenzyl and 1.7 g of 4-piperidinecarboxamide in 20 ml of tetrahydrofuran and 10 ml of water was stirred at 70° C. for 10 hours. The reaction mixture was concentrated and to the residue was added 1 N NaOH aqueous solution. The resultant crystals were filtered, washed well with water and then recrystallized from ethanol to give 1.9 g (82% yield) of 2-[2-(4-carbamoylpiperidino)ethoxy]bibenzyl, m. p. 60°-63° C.

出典